Drs. Laura Stabile, PhD & Timothy Burns, MD/PhD, University of Pittsburgh and the UPMC Hillman Cancer Center
Lung cancer is the leading cause of cancer death in women, killing more women each year than breast, uterine and ovarian cancers combined. Sex differences in non-small cell lung cancer (NSCLC) and survival suggest that estrogen plays a critical factor in the formation of tumors in women’s lungs.
Preclinical and epidemiological studies have demonstrated that the estrogen pathway is a driver of NSCLC progression in women. Results of this project will provide a mechanistic understanding of the role of estrogen on immune suppression and whether hormonal blockade can improve the response rate or durability of response in women with this type of cancer that are treated with targeted immunotherapy.
Laura Stabile, PhD is a Research Associate Professor in the Department of Pharmacology & Chemical Biology at the University of Pittsburgh and a member of the Lung Cancer Program at the UPMC Hillman Cancer Center. In addition to her research and teaching commitments, Dr. Stabile is an active member of the UPMC Women’s Task Force Committee, Clinical Protocol Review Committee, Animal Facility Advisory Committee, and the Cell and Tissue Imaging Facility Advisory Committee.
Dr. Stabile completed her undergraduate degree from Washington & Jefferson College and earned a Ph.D. in Biochemistry from West Virginia University. She completed her post-doctoral training at the University of Pittsburgh where she remained to continue her academic career as faculty.
For more than 15 years, her research efforts have focused on the role of growth factors and hormones in the development of upper aerodigestive tract malignancies with the overall goal of identifying effective targeted therapies for cancer treatment and prevention. During this time, she received multiple awards including the Flight Attendant Medical Research Institute Young Clinical Scientist Award, a Joan’s Legacy Foundation Award, a Lung Cancer Research Foundation Award as well as NIH support for her research. Preclinical laboratory findings have identified that estrogen signaling promotes proliferation in lung tumor preclinical models and have led to clinical trials examining the effectiveness of anti-estrogens combined with targeted therapies for advanced lung cancer.
To date, her work has resulted in 43 peer-reviewed publications, 6 review articles and 4 book chapters. The proposed project seeks to expand on new preliminary data demonstrating hormonal regulation of the lung tumor micro-environment with the overall goal to test the efficacy of combining hormonal therapy with immunotherapy to inhibit estrogen signaling on both lung tumor cells and immune cells. As a translational research scientist with a strong interest in the clinical development of therapies to target the estrogen signaling pathway and further understanding lung cancer in women, she is excited about this project.
Dr. Timothy Burns, MD/PhD is an Assistant Professor of Medicine and Pharmacology & Chemical Biology at the University of Pittsburgh and a member of the Lung Cancer Program at the UPMC Hillman Cancer Center. As a physician-scientist and thoracic oncologist who has lost both of this parents to lung cancer and has an active weekly lung cancer clinic, he is personally and professionally committed to finding new therapies for his patients. Dr. Burns completed his undergraduate work at Cornell University and earned his MD degree and PhD degrees in Cell & Molecular Biology at the University of Pennsylvania. He completed his internal medicine residency and hematology-oncology fellowship at Johns Hopkins Hospital, Johns Hopkins School of Medicine. During his training, he received several prestigious awards, including the AACR-AstraZeneca Fellowship for Translational Lung Cancer Research and the ASCO Young Investigator Award. Since arriving at Pittsburgh in 2012, Dr. Burns has worked closely with the Hillman Cancer Center Lung Cancer Program to develop therapies for lung cancer. Dr. Burns continues to see lung cancer patients in the clinic, however, the majority of his time is spent in his research lab at the Hillman Research Pavilion.
His focus is on characterizing key signaling pathways that are critical for the growth of non-small cell lung cancer and to develop novel targeted therapeutic approaches in KRAS-mutant non-small cell lung cancer and other oncogene driven lung cancers. Dr. Burns has received funding from the American Lung Association, the V Foundation, the LUNGevity Foundation, the Sidney Kimmel Foundation for Cancer Research and the Doris Duke Charitable Foundation. To date, Dr. Burns has published 49 cancer related publications. Dr. Burns has worked closely with Dr. Stabile on targeting estrogen signaling in lung cancer and is committed to exploring the combination of fulvestrant and durvalumab in the clinic and developing biomarkers to predict the patients who are likely to respond in hopes of improving survival in women with lung cancer.